The Giant Sea Serpent only has a short appearance in the film King Kong Escapes. When the film's central character Susan Watson and her companions are attempting to leave Mondo Island, the Giant Sea Serpent rises out from the water and approaches their craft. On the shore, King Kong, concerned with the safety of Susan then throws a boulder at the serpent to distract it while Susan Watson and her companions escape the serpent and reach their submarine. King Kong goes into the water, and is attacked by the Giant Sea Serpent, who attempts to constrict Kong. After a brief skirmish, Kong frees himself from the Giant Sea Serpent's grasp and tosses him back into the water.